Psychosocial phenotypic aging dimensions

Psychosocial phenotypic aging dimensions predict disease incidence in humans.

“dimensions reflecting psychosocial factors, particularly cumulative life stress, predicted disease risk as strongly as, or more strongly than, traditional biomedical risk factors”

HumansLifelines cohort; prediction compared with traditional biomedical risk factorsn = 150,000

PUMA: A Phenotypic Unsupervised Model of Aging Reveals Distinct Aging Dimensions

bioRxiv (Cold Spring Harbor Laboratory)·27 Jul 2026Preprint