Phenotypic aging dimensions

1. Phenotypic aging dimensions are associated with future incidence of cancer, diabetes, COPD, heart failure, stroke, and Parkinson’s disease in humans.

   “These dimensions were significantly associated with the future incidence of major age-related diseases—including cancer, diabetes, COPD, heart failure, stroke, and Parkinson’s disease—”

   HumansLifelines cohortn = 150,000

   PUMA: A Phenotypic Unsupervised Model of Aging Reveals Distinct Aging Dimensions

   bioRxiv (Cold Spring Harbor Laboratory)·27 Jul 2026Preprint

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