Proinflammatory cytokines

Biomarker

1 paper1 finding

  • Cells1

Upstream

1

gata4

upin human cells1

1 study
  1. gata4 induces proinflammatory cytokines in human cells.

    Cellsin vitrochondrocytes

    Aging-associated increase of GATA4 levels in articular cartilage is linked to impaired regenerative capacity of chondrocytes and osteoarthritis

    eLife12 Aug 2026

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NPJ Aging

Human protein variant eased signs of progeria in mice

An animal experiment in genetically engineered mice found that the variant prevented characteristic tissue changes and modestly increased median lifespan.An animal experiment in genetically engineered mice found that the variant prevented characteristic tissue changes and modestly increased median lifespan.

Experiments in miceInterventions
The Journal of Pharmacology and Experimental Therapeutics

TRPM3 inhibition reverses depressive behaviors in rats

In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like…In ovariectomized rats, inhibiting TRPM3 with naringenin restored serotonin signaling and dendritic arborization while reducing neuroinflammation and depressive-like deficits.

Experiments in ratsMechanisms