PCBrainAge deviation

1. Smoking is associated with PCBrainAge deviation in humans (+6.4 years, CI [2.5, 10.3]).

   “smoking was associated with a higher DNAmAge deviation (PCBrainAge + 6.4 years in prefrontal cortex, CI [2.5, 10.3], p = 0.004).”

   Humansprefrontal cortex

   Brain DNA Methylation Age, Lifestyle Factors and Dementia in the Swedish Twin Registry

   Aging cell·10 Jun 2025

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