PARP activation

1 paper

Animals1

Latest

4 in 12 months

Tissue & Cell26 Jun

CD38-driven NAD⁺ depletion governs crypt structure and barrier dysfunction in fluorouracil-induced colonic mucositis: From metabolic collapse to architectural remodeling

Experiments in miceNAD+ metabolism

JCI Insight10 Feb

Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis

Experiments in animalsInterventions

Journal of Translational Medicine31 Jan

Nutrition and longevity - diet in centenarians

ReviewDiet

Translational Oncology7 Jan

First functional evidence that a rare germline TP53β variant drives senescence-associated immune suppression and impairs apoptosis and cell migration in breast cancer patients

Cohort study in peopleApoptosis

Stem Cell Reports27 Sep

Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1

Experiments in cellsMechanisms

ChemRxiv24 Jul

Boosting NAD+ for Anti-Aging: Mechanisms, Interventions, and Opportunities

Preprint: reviewInterventions

Nucleic Acids Research18 Jun

Replication stress responses in human lymphocytes change sex-specifically during aging

Study in peopleMechanisms

Aging3 Apr

Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation

Experiments in cellsInterventions

Rejuvenation Research1 Jun

The NAD+/PARP1/SIRT1 Axis in Aging

ReviewInterventions

Cell Metabolism4 Nov

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

Experiments in miceInterventions