p66Shc
2 papers study it56 more mention it
- Humans1
- Animals1
Funding
1 grant since 2019National Heart, Lung, and Blood InstituteUS$1.6m
Latest
4 papers in 12 monthsScientific Reports
Hierarchical random forest model, inflammation and oxidative stress as predictors of the atherogenic index of plasma and diabetes progression
Cross-sectional study in peopleAtherogenic index of plasma
Mechanisms of Ageing and Development
Metformin therapy increases leukocyte telomere length, telomerase activity, and longevity gene expression in Asian Indians with prediabetes: A 24-week participant-blind, outcome-assessor-blinded randomized controlled trial
Randomized trial in 127 peopleMetformin
Biology of Reproduction
O-GlcNAcylation of p66Shc drives senescence-associated secretory phenotype via mitochondrial DNA release in gestational diabetes mellitus†
Experiments in human cellsSenescence-associated secretory phenotype (SASP)
International Journal of Molecular Sciences
Protective Role of p66Shc Deletion in Physiological Renal Aging: Effects on G Protein-Coupled Receptor 124 Expression and Associated Cellular Senescence
Experiments in miceCellular senescence
Cell Communication and Signaling
High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
Experiments in animalsAutophagy
Aging and Disease
The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung
Experiments in miceLung
Cell Death & Disease
p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence
Experiments in mouse cellsAutophagy
European Heart Journal
Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice
Experiments in miceSirtuin signaling