NLRP3 activation

2 papers

Animals1
Cells1

Latest

15 in 12 months

medRxiv8 Oct

NLRP3 Activation and Impaired TGF-β Anti-Inflammatory Pathways Predict Vascular Risk in PWH on ART

Preprint: cohort study of 1,002 peopleVascular disease

Bulletin of Experimental Biology and Medicine29 Sep

NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages

Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.

Experiments in cellsNLRP3 inflammasome

American Journal of Transplantation8 Sep

NLR family pyrin domain containing 3-mediated Kupffer cell pyroptosis aggravates ischemia-reperfusion injury after aging donor liver transplantation through CD38-nicotinamide adenine dinucleotide⁺-sirtuin 1-dependent acetylation of estrogen-related receptor α

Experiments in micePyroptosis

Physiological Research8 Sep

Targeting Mitochondria in MASLD: Comparative Evaluation of MitoQ and SS-31 (Elamipretide) in Aged Female Mice under Nutritional Stress

Experiments in miceInterventions

Ageing Research Reviews15 Jul

Modulation of inflammasome biology in age-associated neurodegenerative diseases: Therapeutic potential of endogenous gasotransmitters and synthetic molecules

ReviewNeurodegenerative disease

Advanced Science6 Jul

Targeting NSUN2-Mediated m⁵C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Experiments in miceCellular senescence

International Immunopharmacology10 May

NLRP3 inflammasome dysregulation by endocrine-disrupting chemicals and heavy metals: Developmental programming, sex differences, and inflammaging across the lifespan

ReviewNLRP3 inflammasome

Nature Communications8 Apr

Lactate metabolism reprogramming through orthogonal tandem catalysis to reverse intervertebral disc degeneration

Experiments in animalsInterventions

Frontiers in Cell and Developmental Biology23 Mar

Immune-metabolic positive feedback model in COPD: cross-mechanisms and potential intervention strategies

ReviewNAD+ metabolism

Biogerontology4 Mar

Dual roles of basal NLRP3 expression in cognitive and neurogenic aging

Experiments in miceNLRP3