Nicotinamide mononucleotide availability

Biomarker

1 paper1 finding

Animals1

Upstream

CD38

downin animals1

1 study

CD38 decreases nicotinamide mononucleotide availability.
“depletes the precursor nicotinamide mononucleotide (NMN) required for NAD+ salvage synthesis, thereby impairing NMN availability and osteogenic capacity in neighboring bone marrow mesenchymal stem cells.”
AnimalsSTING-driven CD38 upregulationbone marrow mesenchymal stem cell
Immune protein has opposing roles in bone as animals age
Advanced science (Weinheim, Baden-Wurttemberg, Germany)15 Oct 2026

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Advanced Science6 h

Immune protein has opposing roles in bone as animals age

Animal experiments found that loss of an immune-signalling protein harmed early bone development but protected against age-related bone loss from middle age onward.Animal experiments found that loss of an immune-signalling protein harmed early bone development but protected against age-related bone loss from middle age onward.

Experiments in animalsImmune response

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Nicotinamide mononucleotide availability

Upstream

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Immune protein has opposing roles in bone as animals age

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