Neutrophil extracellular traps

1. Resatorvid inhibits neutrophil extracellular traps in mice.

   “Targeting TLR4 can mitigate inflammatory responses and enhance cardiac function in HF mice by inhibiting NETs formation.”

   Animalsin isoproterenol-induced heart failuredaily intraperitoneal injectionsmyocardium2 mg/kg7 consecutive daysmales

   Targeting the Toll-Like Receptor 4 Ameliorates Heart Failure in Aged Mice by Inhibiting the Formation of Neutrophil Extracellular Traps

   Physiological research·11 Mar 2026

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1. Young bone marrow transplantation decreases neutrophil extracellular traps in mice (MD = -0.33%, 95% CI, -0.43% to -0.22%).

   “Consistently, transplantation of young bone marrow into aged recipients significantly reduced NET accumulation (MD = -0.33%, 95% CI, -0.43% to -0.22%; P < .001).”

   Animalssepsis (cecal ligation and puncture)

   Impaired AMP-Dependent Protein Kinase-Mediated Neutrophil Extracellular Trap Clearance by Aged Macrophages in Sepsis-Induced Liver Injury

   Anesthesia and analgesia·20 Nov 2025

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1. Frailty increases neutrophil extracellular traps in humans.

   “FR neutrophils also released significantly more NETs in response to LPS (10 ng/ml, n = 6-7, P < 0.05).”

   Humansin response to LPS10 ng/ml

   Altered neutrophil signalling linked to impaired chemotaxis and increased ROS and NET production in older people with frailty

   Clinical and experimental immunology·6 Jan 2026

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