Resatorvid

2 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: Austrian Science Fund and 2 more

Animals2

Outcomes

cTnI

downin mice1

1 study

Resatorvid decreases cTnI in mice.
“Concurrently, it also decreased the serum levels of MPO-DNA, NE-DNA, NT-proBNP, cTnI, and inflammatory factors.”
Animalsin isoproterenol-induced heart failuredaily intraperitoneal injections2 mg/kg7 consecutive daysmales
Targeting the Toll-Like Receptor 4 Ameliorates Heart Failure in Aged Mice by Inhibiting the Formation of Neutrophil Extracellular Traps
Physiological research11 Mar 2026

More on Neutrophil extracellular traps

Collagen fiber deposition

downin mice1

1 study

Resatorvid decreases collagen fiber deposition in mice.
“Inhibition of TLR4 not only markedly improved cardiac function but also alleviated pathological damage to myocardial tissue and reduced collagen fiber deposition.”
Animalsin isoproterenol-induced heart failuredaily intraperitoneal injectionsmyocardium2 mg/kg7 consecutive daysmales
Targeting the Toll-Like Receptor 4 Ameliorates Heart Failure in Aged Mice by Inhibiting the Formation of Neutrophil Extracellular Traps
Physiological research11 Mar 2026

Cardiac function

upin mice1

1 study

Resatorvid improves cardiac function in mice.
“Inhibition of TLR4 not only markedly improved cardiac function but also alleviated pathological damage to myocardial tissue and reduced collagen fiber deposition.”
Animalsin isoproterenol-induced heart failuredaily intraperitoneal injectionsmyocardium2 mg/kg7 consecutive daysmales
Targeting the Toll-Like Receptor 4 Ameliorates Heart Failure in Aged Mice by Inhibiting the Formation of Neutrophil Extracellular Traps
Physiological research11 Mar 2026

Insulin secretion

upin mice1

1 study

Resatorvid improves insulin secretion in mice.
“reduced insulitis, macrophage infiltration, and fibrosis, while preserving insulin secretion.”
Animalsfour months
Islet Inflammation and Endocrine Function in Aging - Evaluating the Role of Toll-like receptor 4
Aging and disease5 Dec 2025

Extracellular matrix remodelling

downin mice1

1 study

Resatorvid decreases extracellular matrix remodelling in mice.
“Aged C57BL/6J mice were treated with the TLR4 inhibitor TAK-242 for four months, which reduced insulitis, macrophage infiltration, and fibrosis, while preserving insulin secretion.”
Animalsfour months
Islet Inflammation and Endocrine Function in Aging - Evaluating the Role of Toll-like receptor 4
Aging and disease5 Dec 2025

More on Extracellular matrix remodelling

Macrophage infiltration

downin mice1

1 study

Resatorvid decreases macrophage infiltration in mice.
“Aged C57BL/6J mice were treated with the TLR4 inhibitor TAK-242 for four months, which reduced insulitis, macrophage infiltration, and fibrosis, while preserving insulin secretion.”
Animalsfour months
Islet Inflammation and Endocrine Function in Aging - Evaluating the Role of Toll-like receptor 4
Aging and disease5 Dec 2025

Insulitis

downin mice1

1 study

Resatorvid decreases insulitis in mice.
“Aged C57BL/6J mice were treated with the TLR4 inhibitor TAK-242 for four months, which reduced insulitis, macrophage infiltration, and fibrosis, while preserving insulin secretion.”
Animalsfour months
Islet Inflammation and Endocrine Function in Aging - Evaluating the Role of Toll-like receptor 4
Aging and disease5 Dec 2025