Neutralising antibodies

2 papers2 findings

Human trial1
Humans1

Interventions

1

Spermidine

upin humans1

1 study

Spermidine increases neutralising antibodies in humans.
“Spermidine reversed these features and significantly enhanced spike-specific IgG secretion, memory B cell recall responses and neutralising antibody activity, specifically in non-responders.”
Human trialin vaccine non-responders6 mg daily13 weeksn = 40
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study
Aging cellMay 22, 2026

More on Spermidine

Associations

1

IFNγ-secreting CD4+ T cells

downin humans1

1 study

IFNγ-secreting CD4+ T cells are associated with neutralising antibodies in humans.
“Antigen-specific interferon-γ (IFNγ)-secreting CD4+ T-cells to wild-type and Omicron antigens increased in young adults, which was strongly positively correlated with their neutralising antibody responses. Conversely, this relationship was negative in older adults.”
Human trialafter two doses of BNT162b2 mRNA vaccine
Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults
Aging cellFeb 5, 2024

More on IFNγ-secreting CD4+ T cells

Latest

2 in 12 months

Aging CellMay 22

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study

Randomized trial in 40 peopleSpermidine

Molecular Imaging and BiologyNov 26

Sarcopenia in Aging: Pathogenesis, Diagnosis, and Emerging Therapeutic Frontiers

ReviewSarcopenia

GutOct 9

Crosstalk between liver sinusoidal endothelial cells and hepatocytes via IL-1α-IL1R1 axis exacerbates ischaemia/reperfusion injury in aged livers

Experiments in ratsMechanisms

Life SciencesFeb 27

Aging-related hyperphosphatemia triggers the release of TNF-α from macrophages, promoting indicators of sarcopenia through the reduction of IL-15 expression in skeletal muscle

Experiments in miceSarcopenia

Oral DiseasesOct 28

Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain

Experiments in miceMechanisms

Immunity & AgeingJun 28

Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19

Study in peoplePopulations

Research SquareMay 24

Centenarians, Semi and Supercentenarians, COVID-19 and Spanish Flu: a serological assessment to gain insight into the resilience of older centenarians to COVID- 19

Preprint: cross-sectional study of 33 peopleMechanisms

Aging CellFeb 6

Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults

Study in peopleImmune response

Cell and Tissue ResearchOct 23

Platelet lysate can support the development of a 3D-engineered skin for clinical application

Experiments in cellsInterventions

Aging CellAug 19

B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction

Experiments in animalsMechanisms