IFNγ-secreting CD4+ T cells

1. IFNγ-secreting CD4+ T cells are associated with neutralising antibodies in humans.

   “Antigen-specific interferon-γ (IFNγ)-secreting CD4+ T-cells to wild-type and Omicron antigens increased in young adults, which was strongly positively correlated with their neutralising antibody responses. Conversely, this relationship was negative in older adults.”

   Human trialafter two doses of BNT162b2 mRNA vaccine

   Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults

   Aging cell·5 Feb 2024

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