Naïve T cell abundance

3 papers1 finding

Humans1
Animals2

Upstream

1

GHR

downin mice1

1 study

GHR decreases naïve T cell abundance in mice.
“T cell populations in aged GHR-/- mice showed higher levels of naïve T cells”
Animalsshown by Ghr knockout compared with wild-type controlsthymus, bone marrow, spleen, and bloodfemales
The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells
Pituitary12 Jan 2026

Latest

3 in 12 months

bioRxiv4 May

Multimodal analysis of molecular remodeling in aging spleen identified global and cell type specific changes

Preprint: experiments in miceMechanisms

American Journal of Physiology Regulatory, Integrative and Comparative Physiology24 Apr

Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration

Study in peopleBlood and immune system

Pituitary12 Jan

The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells

Experiments in miceGrowth hormone axis