N(epsilon)-(carboxymethyl)lysine

3 papers2 findings

Animals3

Interventions

1

Caloric restriction

downin rats1−25%

1 study

Caloric restriction decreases N(epsilon)-(carboxymethyl)lysine in rats (-25%).
“however, CR significantly reduced levels of CML (25%), pentosidine (50%), and fluorescence (15%) in collagen in the oldest rats.”
Animalsskin25 months
Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen
The journals of gerontology. Series A, Biological sciences and medical sciences1 Nov 1995

More on Caloric restriction

Associations

1

Lifespan

downin Mammalia1

1 study

N(epsilon)-(carboxymethyl)lysine is associated with lifespan in Mammalia.
“The steady-state levels of malondialdehyde-lysine and Nepsilon-carboxymethyl lysine are directly related to the peroxidizability index and inversely related to the MLSP.”
Animalsliver
Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans
The journals of gerontology. Series A, Biological sciences and medical sciences1 Jun 2000

Latest

Experimental Gerontology1 Oct

Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon

Experiments in ratsUbiquitin–proteasome system

The Journals of Gerontology, Series A1 Jun

Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans

Experiments in animalsMechanisms

The Journals of Gerontology, Series A1 Nov

Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N epsilon-(carboxymethyl)lysine and pentosidine, in rat skin collagen

Experiments in ratsDietary restriction