Motoric cognitive risk syndrome: aging research evidence

Associations

2

Mortality

upin humans4HR 1.54

4 studies

Motoric cognitive risk syndrome predicts mortality in humans (HR 1.540, 95% CI 1.169-2.028).
“This association remained significant even after adjusting for sex, age, area, education level, marital status, chronic diseases, and lifestyle factors (HR = 1.540, 95% CI 1.169-2.028).”
Humansafter adjusting for sex, age, area, education level, marital status, chronic diseases, and lifestyle factors8-yearn = 1,683
Self-reported motoric cognitive risk syndrome predicts long-term mortality in older adults
The journal of nutrition, health & agingMay 14, 2025
Motoric cognitive risk syndrome raises the risk of mortality in humans (1.60, 95% CI 1.17-2.19).
“mortality: MCR 1.60, 95% CI 1.17-2.19; CF 3.26, 95% CI 1.99-5.33; and PCDS 1.58, 95% CI 1.17-2.13”
Humansadjusting for multiple confoundersdecade-long follow-up periodn = 2,367
Comparison of 3 Aging Metrics in Dual Declines to Capture All-Cause Dementia and Mortality Risk: Cohort Study
JMIR agingJan 30, 2025
Motoric cognitive risk syndrome predicts mortality in humans (OR 1.27, 95% CI 1.00–1.62).
“Each metric predicted mortality after adjustment for age and sex, with some variations in the strength of the associations”
HumansCHARLS; adjusted for age and sex
Aging metrics incorporating cognitive and physical function capture mortality risk: results from two prospective cohort studies
BMC geriatricsApr 28, 2022
Motoric cognitive risk syndrome predicts mortality in humans.
“studies have shown MCR as a predictor of other negative outcomes in older adults, including disability, falls and death.”
Review
Motoric Cognitive Risk Syndrome: Predictor of Dementia and Age-Related Negative Outcomes
Frontiers in medicineOct 25, 2017

Dementia

upin humans2OR 1.9

2 studies

Motoric cognitive risk syndrome raises the risk of dementia in humans (OR 1.90, 95% CI 1.30-2.78).
“All 3 metrics were predictive of incident all-cause dementia and mortality when adjusting for multiple confounders, with variations in the strength of their associations (incident dementia: MCR odds ratio [OR] 1.90, 95% CI 1.30-2.78”
Humansadjusting for multiple confoundersdecade-long follow-up periodn = 2,367
Comparison of 3 Aging Metrics in Dual Declines to Capture All-Cause Dementia and Mortality Risk: Cohort Study
JMIR agingJan 30, 2025
Motoric cognitive risk syndrome predicts dementia in humans.
“a possible approach to identify individuals at increased risk of dementia.”
Review
Motoric Cognitive Risk Syndrome: Predictor of Dementia and Age-Related Negative Outcomes
Frontiers in medicineOct 25, 2017

Funding

4 grants since 2020

National Institute on AgingUS$3.5mSwiss National Science FoundationCHF 720kCanadian Institutes of Health Research (CIHR) Project GrantCA$132.5k

Latest

28 in 12 months

BMC GeriatricsOct 15

Association of the C-reactive protein-triglyceride glucose index with motoric cognitive risk syndrome in Chinese older adults: a cross-sectional study

Cross-sectional study of 4,002 peopleC-reactive protein-triglyceride-glucose index

Paper

MaturitasOct 14

Multi-domain interventions for the prevention of motoric cognitive risk syndrome among Chinese older adults: An application of the parametric G-formula based on an intrinsic capacity framework

Cohort study of 2,299 peopleMotoric cognitive risk syndrome

Paper

Practical GeriatricsOct 10

Prevalence of motoric cognitive risk syndrome in hospitalized elderly patients with chronic pain and its influencing factors

Cross-sectional study of 347 peopleMotoric cognitive risk syndrome

Paper

BMC GeriatricsOct 8

Early dementia signs tended to link to higher cancer risk

In an observational study of 2,590 dementia-free adults, individuals with early cognitive and walking difficulties tended to have an increased risk of cancer.In an observational study of 2,590 dementia-free adults, individuals with early cognitive and walking difficulties tended to have an increased risk of cancer.

Cohort study of 2,590 peopleCancer

Paper

BMJ OpenOct 2