Motor decline

Biomarker

1 paper

Animals1

Latest

31 in 12 months

Frontiers in Pharmacology8 Oct

Formononetin improved healthspan via the P53/P21/CDK4 pathway in SAMP8 mice and DAF-16/SKN-1 signaling pathway in C.elegans

Experiments in miceInterventions

Paper

bioRxiv8 Oct

A bone hormone reverses age-related movement decline in mice

In mice, restoring the hormone osteocalcin improved motor function in old age by supporting cellular recycling and energy production in spinal motor neurons.In mice, restoring the hormone osteocalcin improved motor function in old age by supporting cellular recycling and energy production in spinal motor neurons.

Preprint: experiments in miceBones and joints

Paper

International Neurourology Journal7 Oct

Exercise-Induced Activation of IGF-1/mTOR Signaling and Hippocampal BDNF/PGC-1α Expression Reverses Age-Related Motor Decline

Experiments in miceInterventions

Paper

bioRxiv5 Oct

Restoring Tyr1R signaling aids motor function in flies

Overexpressing the receptor in adrenergic-like neurons prolonged lifespan, restored calcium signaling, and improved locomotor performance in aged fruit flies.Overexpressing the receptor in adrenergic-like neurons prolonged lifespan, restored calcium signaling, and improved locomotor performance in aged fruit flies.

Preprint: experiments in fliesInterventions

Paper

The Journal of Experimental Medicine16 Sep