MMP-2 and MMP-9

There are 4 papers on MMP-2 and MMP-9 in aging research: none in people yet, 3 in animals, 1 in cells.

4 papers study it24 more mention it2 findings

2 new papers in 30 daysSee all 28 papers on MMP-2 and MMP-9

Animals3
Cells1

Interventions

2

Rapamycin

downin mouse cells1

1 study

Rapamycin decreases MMP-2 and MMP-9 in aortic smooth muscle cells isolated from mgR/mgR mice.
“expression of mTOR, p-RPS6, tumour necrosis factor α, matrix metalloproteinase-2 and -9 was significantly suppressed by rapamycin”
Cellsin aortic smooth muscle cells isolated from mgR/mgR miceaortic smooth muscle cell
Short-term rapamycin treatment increases life span and attenuates aortic aneurysm in a murine model of Marfan-Syndrome
Biochemical pharmacologyOct 2, 2022

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Acarbose

downin cells1

1 study

Acarbose decreases MMP-2 and MMP-9 in cells.
“Acarbose also inhibited the phosphorylation of focal adhesion kinase (FAK) and Akt, activities of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9”
Cells
Acarbose inhibits the proliferation and migration of vascular smooth muscle cells via targeting Ras signaling
Vascular pharmacologyFeb 9, 2018

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Latest

3 papers in 12 months

Biochemical PharmacologyOct 2

Short-term rapamycin treatment increases life span and attenuates aortic aneurysm in a murine model of Marfan-Syndrome

Experiments in miceRapamycin

Journal of Ginseng ResearchMay 25

Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

Experiments in ratsRenal fibrosis

Vascular PharmacologyFeb 9

Acarbose inhibits the proliferation and migration of vascular smooth muscle cells via targeting Ras signaling

Experiments in cellsInterventions

International Journal of CardiologyMay 28

Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress

Experiments in miceAtherosclerosis

GeroScienceOct 27

Sonic hedgehog-matrix metalloproteinase crosstalk in neurovascular ageing and stroke: a potential mechanistic link

ReviewMechanisms

BiomedicinesOct 27

The Diabetes Paradox in Aortic Aneurysms: An Unexpected Inverse Association

ReviewMechanisms

International Journal of Molecular SciencesMar 14

MMP-2 and MMP-9 Gene Polymorphisms and Serum Levels in Relation to Insulin Resistance in a Polish Cohort

Case-control study of 200 peopleMMP-2

MicrocirculationFeb 18

Small Arteries From Old Spontaneously Hypertensive Rats Exhibit Enhanced Endothelium-Independent Vasodilatory Capacity and Reduced Stiffness

Case-control study in peopleMechanisms

Naunyn-Schmiedeberg's Archives of PharmacologyAug 20

Therapeutic use of fisetin and pirfenidone combination in bleomycin-induced pulmonary fibrosis in adult male albino rats

Experiments in 40 ratsFisetin

Brain Research BulletinNov 9

Inhibition of MMP-2 and MMP-9 attenuates surgery-induced cognitive impairment in aged mice

Experiments in animalsMechanisms

See all 28 papers on MMP-2 and MMP-9