mtDNA D-loop methylation
1 paper3 findings
- Humans1
Effects
1Nuclear DNA methylation
no changein humans1
1 study
Nuclear DNA methylation
no changein humans1
mtDNA D-loop methylation has no effect on nuclear DNA methylation in humans.
“we cannot find relationships between the methylation levels of mtDNA and nuclear DNA”
Humans
GeroScience17 Jan 2026
Upstream
1Olympic champion status
downin humans1
1 study
Olympic champion status
downin humans1
Olympic champion status decreases mtDNA D-loop methylation in humans (~ 36% unadjusted mean difference, p = 0.016).
“The D-loop methylation level of the Olympic champions (N = 58) was significantly lower than that of non-champions (N = 32) (~ 36% unadjusted mean difference p = 0.016, sex and age adjusted p = 0.017).”
Humans
GeroScience17 Jan 2026
Associations
1Biological sex
upin humans1
1 study
Biological sex
upin humans1
Biological sex is associated with mtDNA D-loop methylation in humans (estimate = 1.521, p = 0.033).
“the robust linear analysis revealed that biological sex is a significant factor in mtDNA D-loop methylation (estimate = 1.521, p = 0.033).”
Humans
GeroScience17 Jan 2026
Latest
1 in 12 monthsGeroScience
Epigenetic insights of Olympic champions: nuclear and mitochondrial DNA methylation and regulators of aging
Cross-sectional study in peopleDNA methylation