Mitochondrial DNA abundance

1. rare genetic variants identified in long-lived individuals decrease mitochondrial DNA abundance in mouse cells.

   “We identified alterations in lipid and mitochondrial metabolism, including a reduction in mitochondrial DNA levels, which were mostly shared among all variants.”

   CellsMostly shared among the rare variantsembryonic stem cell

   Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

   bioRxiv (Cold Spring Harbor Laboratory)·28 May 2026Preprint

1. mip-1 decreases mitochondrial DNA abundance in N. crassa cells.

   “A dosage analysis by next-generation sequencing reads suggested that mitochondrial DNA (mtDNA) sequences are decreased nonuniformly throughout the genome of the ms1 strain.”

   Cellsms1 strain carrying the mip-1 L814R mutation; nonuniform decrease across the mitochondrial genome

   A mutation in DNA polymerase γ harbors a shortened lifespan and high sensitivity to mutagens in the filamentous fungus Neurospora crassa

   Genetics·29 Nov 2024

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