mip-1

1. mip-1 decreases mitochondrial DNA abundance in N. crassa cells.

   “A dosage analysis by next-generation sequencing reads suggested that mitochondrial DNA (mtDNA) sequences are decreased nonuniformly throughout the genome of the ms1 strain.”

   Cellsms1 strain carrying the mip-1 L814R mutation; nonuniform decrease across the mitochondrial genome

   A mutation in DNA polymerase γ harbors a shortened lifespan and high sensitivity to mutagens in the filamentous fungus Neurospora crassa

   Genetics·29 Nov 2024

More on Mitochondrial DNA abundance

1. mip-1 increases mutagen sensitivity in N. crassa cells.

   “The mutation responsible for the short lifespan and mutagen sensitivity in the ms1 strain was identified in DNA polymerase γ (mip-1:NCU00276).”

   Cellsms1 strain carrying the mip-1 L814R mutation; exposure to hydroxyurea or ultraviolet radiation

   A mutation in DNA polymerase γ harbors a shortened lifespan and high sensitivity to mutagens in the filamentous fungus Neurospora crassa

   Genetics·29 Nov 2024

1. mip-1 shortens lifespan in N. crassa cells.

   “The mutation responsible for the short lifespan and mutagen sensitivity in the ms1 strain was identified in DNA polymerase γ (mip-1:NCU00276).”

   Cellsms1 strain carrying the mip-1 L814R mutationhypha

   A mutation in DNA polymerase γ harbors a shortened lifespan and high sensitivity to mutagens in the filamentous fungus Neurospora crassa

   Genetics·29 Nov 2024