Pluripotency signature

rare genetic variants identified in long-lived individuals increase pluripotency signature in mouse cells.

“All variant mESC lines exhibited a signature implying increased pluripotency.”

CellsAll variant mESC linesembryonic stem cell

Rare genetic variants in the IIS/mTOR signalling pathway identified in exceptionally long-lived individuals show shared in vitro effects associated with lifespan across species

bioRxiv (Cold Spring Harbor Laboratory)·28 May 2026Preprint