There are 3 papers on miR-186-5p in aging research: 2 observational studies in people, 1 in animals.
3 papers study it2 more mention it5 findings
See all 5 papers on miR-186-5p
“A negative association was observed between SIRT6 mRNA and miR-186-5p (rs = -0.25, p = 0.026)”
- Humans2
- Animals1
Effects
3IFNA2
downin human cells1
1 study
IFNA2
downin human cells1
miR-186-5p inhibits IFNA2 in human cells (luciferase assays).
“luciferase assays confirmed IFNA2 as a direct target of miR-186-5p.”
Cellsluciferase assays
Antioxidants (Basel, Switzerland)
Glucose-stimulated insulin secretion
upin human cells1
1 study
Glucose-stimulated insulin secretion
upin human cells1
miR-186-5p improves glucose-stimulated insulin secretion in pancreatic β-cells exposed to glucolipotoxic stress.
“Restoration of miR-186-5p or pharmacologic JAK inhibition mitigated these defects”
Cellsin pancreatic β-cells exposed to glucolipotoxic stress
Antioxidants (Basel, Switzerland)
Oxidative stress and ROS signaling
downin human cells1
1 study
Oxidative stress and ROS signaling
downin human cells1
miR-186-5p decreases oxidative stress and ROS signaling in pancreatic β-cells exposed to glucolipotoxic stress.
“Restoration of miR-186-5p or pharmacologic JAK inhibition mitigated these defects”
Cellsin pancreatic β-cells exposed to glucolipotoxic stress
Antioxidants (Basel, Switzerland)
Upstream
1Prediabetes
downin humans1
1 study
Prediabetes
downin humans1
Prediabetes are linked with lower miR-186-5p in prediabetes.
“Six EV miRNAs, including miR-186-5p, were consistently reduced in prediabetes and correlated with glycemic and insulin resistance indices.”
Humansin prediabetes
Antioxidants (Basel, Switzerland)
Associations
1SIRT6
downin humans1
1 study
SIRT6
downin humans1
miR-186-5p is associated with SIRT6 in humans (rs = -0.25).
“A negative association was observed between SIRT6 mRNA and miR-186-5p (rs = -0.25, p = 0.026)”
Humansperipheral blood mononuclear cells
Epigenetics