Microglial volume

1. Weight loss increases microglial volume in mice.

   “only in mid-aged mice, WL further increased HFD-induced mean single-microglial volume in ARC, corresponding to increased pNFκB-(p-p65) nuclear staining.”

   Animalsafter 8 weeks high-fat dietarcuate nucleus2 weeks

   Weight loss aggravates obesity-induced hypothalamic inflammation in mid-aged mice

   GeroScience·17 Oct 2025

More on Weight loss

1. Crown-like-structure density is associated with microglial volume in mice (Rho = 0.691, p = 0.001).

   “adipose tissue crown-like-structure density correlated with ARC microglial cell volume (Rho(ρ) = 0.691, p = 0.001).”

   Animalsmid-aged weight-losing mice

   Weight loss aggravates obesity-induced hypothalamic inflammation in mid-aged mice

   GeroScience·17 Oct 2025

More on Crown-like-structure density