MDM2 and CDKN1A expression

Biomarker

1 paper1 finding

  • Cells1

Upstream

1

Δ246p53

downin cells1

1 study
  1. Δ246p53 decreases MDM2 and CDKN1A expression in cells.

    “Mechanistically, Δ246p53 interacted with FLp53, leading to a decrease in the expression of downstream target genes HDM2 and p21 .”

    Cellsinteraction with full-length p53

    New protein form pushed lab-grown cells to stop dividing

    Cell death discovery7 Oct 2026

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Cell Death Discovery

New protein form pushed lab-grown cells to stop dividing

Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop dividing.Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop dividing.

Experiments in cellsMechanisms