Papers on loss of homeostasis

52 papers

Thursday, September 24

Nature Reviews NephrologySep 24

The role of senescence in kidney ageing, injury and fibrosis

ReviewCellular senescence

Paper

Tuesday, May 19

Bulletin of Mathematical BiologyMay 19

Damage-Driven Irreversibility and Emergent Senescence in Age-Structured Cell Populations

Computational studyCellular senescence

Paper

Wednesday, April 1

GeroScienceApr 1

Deciphering the molecular landscape of aortic aging: a meta-analysis of bulk RNA sequencing studies in mice

Computational studyMechanisms

Paper

Friday, February 27

Cell Death & DiseaseFeb 27

Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and attenuate cell senescence

Experiments in miceCellular senescence

Paper

Thursday, February 5

Advances in Wound CareFeb 5

In Vivo, Label-Free Multiphoton Microscopy Is Sensitive to Altered Metabolism and Structure in Aged Skin

Experiments in miceBiomarkers

Paper

Wednesday, January 7

CureusJan 7

The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity

ReviewRapamycin

Paper

Saturday, August 16

Ageing Research ReviewsAug 16

Biomarkers of multimorbidity: A systematic review

Systematic reviewMultimorbidity

Paper

Thursday, April 10

bioRxivApr 10

Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and prevent cell senescence

Preprint: experiments in cellsCellular senescence

Paper

Sunday, March 30

Drugs & AgingMar 30

Symptoms of Orthostatic Hypotension and Drugs Affecting Autonomic Function are Associated with the Onset of Frailty in Community-Dwelling Persons Aged 80 Years and Above: A Prospective Observational Study

Cohort study of 372 peopleOrthostatic hypotension

Paper

Friday, February 21

Molecular NeurodegenerationFeb 21

Mechanisms of astrocyte aging in reactivity and disease

ReviewMechanisms

Paper

Thursday, January 2

NatureJan 2

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice

Experiments in miceAI & data

Paper

Friday, December 13

Nature AgingDec 13

Exploring the effects of estrogen deficiency and aging on organismal homeostasis during menopause

ReviewCellular homeostasis

Paper

Monday, August 19

Molecular Biology ReportsAug 19

Aging and physiological barriers: mechanisms of barrier integrity changes and implications for age-related diseases

ReviewMechanisms

Paper

Saturday, May 18

The Journals of Gerontology, Series AMay 18

Linking Aging to Cancer: The Role of Chromatin Biology

ReviewChromatin

Paper

Acta Pharmacologica SinicaMay 18

MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1

Experiments in miceCellular senescence

Paper

Thursday, January 4

bioRxivJan 4

Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlas

Preprint: experiments in miceTranscriptomics

Paper

Tuesday, October 31

bioRxivOct 31

The Molecular Architecture of Variable Lifespan in Diversity Outbred Mice

Preprint: experiments in 110 miceMechanisms

Paper

Wednesday, October 11

GeroScienceOct 11

OVCH1 Antisense RNA 1 is differentially expressed between non-frail and frail old adults

Case-control study of 24 peopleMechanisms

Paper

Thursday, August 31

Frontiers in AgingAug 31

Biological agents and the aging brain: glial inflammation and neurotoxic signaling

ReviewInflammation

Paper

Friday, August 25

MetabolitesAug 25

The Native Microbiome Member Chryseobacterium sp. CHNTR56 MYb120 Induces Trehalose Production via a Shift in Central Carbon Metabolism during Early Life in C. elegans

Experiments in wormsMechanisms

Paper

Wednesday, June 14

The Journals of Gerontology, Series AJun 14

Physiological Dysregulation Proceeds and Predicts Health Outcomes Similarly in Chinese and Western Populations

Cohort study in peopleBiomarkers

Paper

Wednesday, May 17

Aging and DiseaseMay 17

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis

ReviewMechanisms

Paper

Saturday, April 29

Nature AgingApr 29

Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Experiments in wormsmTOR signaling

Paper

Wednesday, March 15

PeerJMar 15

Determinants of age-related decline in walking speed in older women

Cross-sectional study of 187 peoplePopulations

Paper

Friday, November 4

AgingNov 4

IGF1 gene therapy in middle-aged female rats delays reproductive senescence through its effects on hypothalamic GnRH and kisspeptin neurons

Experiments in ratsReproductive system

Paper

Saturday, September 24

CellsSep 24

Links of Cytoskeletal Integrity with Disease and Aging

ReviewMechanisms

Paper

Friday, September 2

BMC BiologySep 2

Multidimensional associations between nutrient intake and healthy ageing in humans

Cohort study of 1,560 peoplePopulations

Paper

Wednesday, April 13

International Journal of Molecular SciencesApr 13

Evaluating the Role of Probiotics in the Prevention and Management of Age-Related Diseases

ReviewProbiotics

Paper

Tuesday, March 8

bioRxivMar 8

Decreased spliceosome fidelity inhibits mTOR signalling and promotes longevity via an intron retention event

Preprint: experiments in wormsmTOR signaling

Paper

Wednesday, February 16

International Journal of Molecular SciencesFeb 16

Genes and Longevity of Lifespan

ReviewMechanisms

Paper