Lonp1 protease activity

Male decreases Lonp1 protease activity in mice.

“mitochondrial proteostasis is more prone to failure in aged males, with a significant decrease in the protease activity of Lonp1”

Animalsaged micehippocampusmales

Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice

Cell death & disease·30 Dec 2025