Lipid class composition

Biomarker

1 paper1 finding

  • Animals1

Upstream

1

SNCA

upin mice1

1 study
  1. SNCA induces lipid class composition in mice.

    “In mouse midbrain, aSyn pathology altered multiple lipid classes, including increased triacylglycerol, ceramide and sphingomyelin and decreased phospholipids.”

    Animalsinduced alpha-synuclein pathologymidbrain

    Alpha-synuclein pathology alters lipids in mice and human cells

    Research Square9 Oct 2026Preprint

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Research Square

Alpha-synuclein pathology alters lipids in mice and human cells

In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent…In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent fasting.

Preprint: experiments in miceMechanisms