LINE1 transcription

1 paper1 finding

Animals1

Upstream

1

CGAS

downin mice1

1 study

CGAS decreases LINE1 transcription in mice.
“Transcription of L1 elements was increased in both cGAS knockout mice and in cGAS siRNA knockdown cells”
Animalsshown by cGAS knockout
cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation
bioRxiv : the preprint server for biology11 Oct 2024Preprint

Latest

bioRxiv17 Oct

cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation

Preprint: experiments in miceTransposable element activity

EMBO Reports13 Jun

The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence

Experiments in cellsMechanisms