LINE-1 retrotransposons

1 paper

Cells1

Latest

4 in 12 months

bioRxiv20 Aug

Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease

Preprint: experiments in human cellsCellular senescence

Mechanisms of Ageing and Development11 Aug

Epigenetic drift and LINE-1 activation in aging brain: Implications for neurodegenerative disease

ReviewEpigenetic regulation of gene expression

GeroScience27 Jul

LINE-1 CpG methylation in canine blood and cortical DNA tracks epigenetic changes with age

Experiments in dogsBiomarkers

Nature Aging23 Jan

Targeting age-related LINE-1 activation alleviates cardiac aging

Experiments in miceInterventions

Contemporary Oncology16 Oct

LINE-1 retrotransposon activation drives age-associated inflammation via cytoplasmic cDNA-STING/type I interferon signalling: therapeutic potential of reverse transcriptase inhibition

ReviewTransposable element activity

eLife25 Sep

Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

Study in peopleMechanisms

eLife26 Aug

Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

Preprint: study in peopleMechanisms

bioRxiv16 Jul

Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation

Preprint: experiments in human cellsTransposable element activity

eLife24 Jun

Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

Preprint: study in peopleMechanisms

The Journal of Neuroscience15 May

Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain

Study in peopleMechanisms