Left ventricular mass index
Biomarker5 papers8 findings
Human studies link higher blood pressure to greater left ventricular mass index; a trial reports reductions with henagliflozin in dialysis patients with HFpEF. One cohort reports a positive association with high baseline aldosterone but none when aldosterone is analysed continuously.
- Human trial1
- Humans4
Interventions
1Henagliflozin
downin humans1Moderate certainty
1 study
Henagliflozin
downin humans1Moderate certainty
Henagliflozin decreases left ventricular mass index in humans (-5.27 g/m2 (95% CI, -10.02 to -0.53 g/m2)).
Human trialin dialysis patients with HFpEFheart24 weeksn = 112
Effects and Safety of Henagliflozin on Cardiac Structure in Dialysis Patients with Heart Failure with Preserved Ejection Fraction · Clinical journal of the American Society of Nephrology : CJASN · 2 Sep 2026
Upstream
1Aldosterone
no changein humans1
1 study
Aldosterone
no changein humans1
Aldosterone has no effect on left ventricular mass index in humans.
Humanscontinuous variable, fully adjusted10 yearsn = 539
Plasma aldosterone and long-term myocardial remodeling: a 10-year prospective analysis from the Tanushimaru Cohort · Journal of human hypertension · 8 Sep 2026
Associations
624-h systolic blood pressure variability
upin humans1
1 study
24-h systolic blood pressure variability
upin humans1
24-h systolic blood pressure variability is associated with left ventricular mass index in humans (β=2.23 g/m2, 95% CI 0.33-4.12).
Humansuntreated white-coat hypertension
Short-Term 24-h Systolic Blood Pressure Variability and Subclinical Target-Organ Damage in White-Coat Hypertension: A Retrospective Cross-Sectional Study · Vascular health and risk management · 16 Sep 2026
Aldosterone
upin humans1OR 1.86
1 study
Aldosterone
upin humans1OR 1.86
Aldosterone raises the risk of left ventricular mass index in humans (OR 1.86, 95% CI 1.21-2.84).
Humansbaseline PAC ≥ 110 pg/mL, fully adjusted10 yearsn = 539
Plasma aldosterone and long-term myocardial remodeling: a 10-year prospective analysis from the Tanushimaru Cohort · Journal of human hypertension · 8 Sep 2026
Fruits and vegetables
downin humans1Very low certainty
1 study
Fruits and vegetables
downin humans1Very low certainty
Fruits and vegetables are associated with left ventricular mass index in humans (-3.7 g/m2 (95% CI: 0.1, 7.2)).
Humans≥ 5 servings/day
School-based blood pressure measurement and its association with left ventricular mass index among adolescents in urban Tanzania · American journal of hypertension · 25 Aug 2026
Sugar
upin humans1Very low certainty
1 study
Sugar
upin humans1Very low certainty
Sugar is associated with left ventricular mass index in humans (+5.4 g/m2 (95% CI: 0.1, 10.7)).
Humans≥ 6 teaspoons/day
School-based blood pressure measurement and its association with left ventricular mass index among adolescents in urban Tanzania · American journal of hypertension · 25 Aug 2026
High BP at only one visit
upin humans1
1 study
High BP at only one visit
upin humans1
High BP at only one visit is associated with left ventricular mass index in humans (+4.5 g/m2 (95% CI: 0.4, 8.6)).
Humansadjusted
School-based blood pressure measurement and its association with left ventricular mass index among adolescents in urban Tanzania · American journal of hypertension · 25 Aug 2026
Sustained high BP
upin humans1
1 study
Sustained high BP
upin humans1
Sustained high BP is associated with left ventricular mass index in humans (+6.4 g/m2 (95% CI: 1.4, 11.4)).
Humansafter adjusting for confounders
School-based blood pressure measurement and its association with left ventricular mass index among adolescents in urban Tanzania · American journal of hypertension · 25 Aug 2026