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Blood flow restriction + exercise

Blood flow restriction + exercise has been studied in 1 paper since 2022: none in people yet, 1 in animals. The research so far is in animals. The newest paper, May 16, 2022: “Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules”.

Intervention

1 paper studies it5 findingsUpdated

See all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Kerman University of Medical Sciences
  • Animals1

What did studies of Blood flow restriction + exercise find?

5

Studies of Blood flow restriction + exercise measured 5 outcomes; the most studied are STAT3 (1 study), oxidative stress and ROS signaling (1) and apoptosis (1).

STAT3

no changein rats1

1 study

  1. Blood flow restriction + exercise showed no clear effect on STAT3 in rats (aging).

    “had no significant effect on P-STAT3 expression”

    Animalsagingheart10 weeksmales

    Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules

    Pflugers Archiv : European journal of physiology

More on STAT3

Oxidative stress and ROS signaling

downin rats1

1 study

  1. Blood flow restriction + exercise decreases oxidative stress and ROS signaling in rats (aging) (P < 0.05).

    “as well MDA to TAC ratio (P < 0.05, compared to the CTL group)”

    Animalsagingheart10 weeksmales

    Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules

    Pflugers Archiv : European journal of physiology

More on Oxidative stress and ROS signaling

Apoptosis

downin rats1

1 study

  1. Blood flow restriction + exercise decreases apoptosis in rats (aging) (P < 0.05).

    “BFR + Ex significantly reduced both BAX and BAX to BCL2 ratio (P < 0.05)”

    Animalsagingheart10 weeksmales

    Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules

    Pflugers Archiv : European journal of physiology

More on Apoptosis

Left ventricular end-diastolic pressure

downin rats1

1 study

  1. Blood flow restriction + exercise decreases left ventricular end-diastolic pressure in rats (aging) (P < 0.05 and P < 0.01).

    “BFR + Ex displayed significantly lower LVEDP (P < 0.05 and P < 0.01 vs. Ex, and other groups, respectively)”

    Animalsagingheart10 weeksmales

    Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules

    Pflugers Archiv : European journal of physiology

More on Left ventricular end-diastolic pressure

Cardiac contractility

upin rats1

1 study

  1. Blood flow restriction + exercise improves cardiac contractility in rats (aging) (P < 0.01).

    “improved heart cardiac contractility (P < 0.01)”

    Animalsagingheart10 weeksmales

    Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules

    Pflugers Archiv : European journal of physiology

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