Late sodium current

1. Cellular senescence increases late sodium current in human cells (Dox-induced senescent-like iCMs compared with untreated iCMs).

   “These effects were largely ascribable to augmented late sodium current (INaL) and reduced delayed rectifier potassium current (Ikr).”

   CellsDox-induced senescent-like iCMs compared with untreated iCMs0.2 μM doxorubicin3 hours

   Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging

   Theranostics·Jul 4, 2022

More on Cellular senescence

1. Older age is associated with late sodium current in C. porcellus cells.

   “The magnitude of INaL was significantly larger in myocytes from old than from young GPs.”

   Cellsventricular myocyte

   Enhanced basal late sodium current appears to underlie the age-related prolongation of action potential duration in guinea pig ventricular myocytes

   Journal of applied physiology (Bethesda, Md. : 1985)·Dec 14, 2017