Lactate/pyruvate ratio

Biomarker

4 papers3 findings

  • Animals3
  • In silico1

Upstream

1

SAMP8 strain

no changein mice1

1 study
  1. SAMP8 strain has no effect on lactate/pyruvate ratio in mice.

    “There were no significant differences in the serum lactate/pyruvate levels between the SAMP8 and SAMR1 mice.”

    AnimalsSAMP8 vs SAMR1

    Tubular aggregates in the skeletal muscle of the senescence-accelerated mouse; SAM

    Mechanisms of ageing and development13 Mar 2000

Associations

2

Intestinal permeability parameters

downin rats1

1 study
  1. Lactate/pyruvate ratio is associated with intestinal permeability parameters in rats.

    “Additionally, there were significant negative correlations between intestinal permeability parameters and L/P ratios.”

    Animalsintestinal tissue and serummales

    Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats

    Biogerontology15 Apr 2024

More on Intestinal permeability parameters

Older age

downin rats1

1 study
  1. Older age is associated with lactate/pyruvate ratio in rats (Approximately threefold lower in older rats).

    “the L/P ratio was found to be approximately threefold lower in the intestinal tissue of the older rats compared to the younger rats (p < 0.002).”

    Animalsintestinal tissuemales

    Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats

    Biogerontology15 Apr 2024

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