Immune checkpoints

Biomarker

2 papers study it276 more mention it1 finding

Humans1
In silico1

Associations

Hepatitis C virus infection

upin humans1

1 study

Hepatitis C virus infection is associated with immune checkpoints in humans.
“13 ICs (BTLA, CD137(4-1BB), CD27, CD28, CD80, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, and TIM-3) and 13 SASP proteins”
Humansafter approximately more than two years of HCV clearanceplasman = 56
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
Immunity & ageing : I & ANov 17, 2023

Funding

1 grant since 2018

National Heart, Lung, and Blood InstituteUS$154k

Immune checkpoint abnormalities in human subjects with clonal hematopoiesis
National Heart, Lung, and Blood InstituteOregon Health & Science UniversityUS$77k2018–2019

Latest

88 papers in 12 months

Research SquareOct 16

Lipid-Lowering Therapy Use and Survival Outcomes in Advanced Renal Cell Carcinoma Treated with Toripalimab Plus Axitinib or Sunitinib: A Post Hoc Analysis of the Phase III RENOTORCH Trial

Preprint: cohort study of 421 peopleKidney

Paper

Critical Reviews in Oncology/hematologyOct 13

Tumor-Associated Immunosenescence: Mechanisms, Biomarkers, and Age-Adaptive Immunotherapy

ReviewMechanisms

Paper

Nature AgingOct 10

Lymph node shrinkage limited cancer recognition in male mice

Mouse experiments found earlier loss of immune cells not yet activated by their targets in males, alongside faster lymph node shrinkage.Mouse experiments found earlier loss of immune cells not yet activated by their targets in males, alongside faster lymph node shrinkage.

Experiments in miceCancer

Paper

Research SquareSep 18