IGFBP7 × TIMP-2

1. Water deprivation increases IGFBP7 × TIMP-2 in humans.

   “product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase-2 (IGFBP7 × TIMP-2) increased after hypohydration (both P < 0.001)”

   Human trialstepwise water restriction concluding with 16 h water deprivation3 daysfemales

   Acute kidney injury biomarker responses in young and older female adults following mild hypohydration

   American journal of physiology. Renal physiology·27 Feb 2026

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1. Heat stress increases IGFBP7 × TIMP-2 in humans (Group-wide Δ0.64 ± 0.95 (pg/min)2).

   “urinary IGFBP7 × TIMP-2 [group-wide: Δ0.64 ± 0.95 (pg/min)2] in young and older adults.”

   Human trialcontrolled hyperthermiawater-perfused suitkidney2°C increase in core temperature

   Gastrointestinal permeability and kidney injury risk during hyperthermia in young and older adults

   Experimental physiology·17 Oct 2024

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