Gut metabolites

2 papers study it27 more mention it

Human trial1
Animals1

Funding

1 grant since 2018

National Institute on AgingUS$3.9m

New mechanistic insights into how the gut metabolite urolithin A extends lifespan and prevents AD
National Institute on AgingBuck Institute for Research on AgingUS$461.5k2018–2023

Latest

4 papers in 12 months

Journal of Food ScienceMar 23

Urolithin A From Gut Metabolite to Therapeutic Agent: Bioavailability, Mechanisms, and Translational Insights

ReviewUrolithin A

ToxinsFeb 26

Uremic Toxin-Driven Vascular Calcification in Chronic Kidney Disease: Molecular Pathways and Integrated Phenotypes

ReviewKidney

Indian Journal of MicrobiologyFeb 19

Microbiome-Metabolomics Reveals the Bidirectional Associations Between Aging and Depression

Experiments in ratsShort-chain fatty acid metabolism

AAIC 2025 AbstractDec 23

Preliminary Results: Examining Outcomes Associated with Adherence to a Mediterranean Diet compared to a Mediterranean Ketogenic Diet Using the ICAN Program

Randomized trial in 31 peopleMediterranean diet

NutrientsSep 25

Eicosapentaenoic Acid and Urolithin a Synergistically Mitigate Heat Stroke-Induced NLRP3 Inflammasome Activation in Microglial Cells

Experiments in mouse cellsUrolithin A

Advanced ScienceJun 20

Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis

Study in peopleCardiac fibrosis

European Journal of Clinical NutritionOct 25

Expression of PGC-1α, PPAR-α and UCP1 genes, metabolic and anthropometric factors in response to sodium butyrate supplementation in patients with obesity: a triple-blind, randomized placebo-controlled clinical trial

Randomized trial in 50 peopleObesity

Ageing Research ReviewsJul 11

Targeting aging with urolithin A in humans: A systematic review

Systematic reviewUrolithin A

Planta MedicaJun 6

Increased Glycolytic Activity Is Part of Impeded M1(LPS) Macrophage Polarization in the Presence of Urolithin A

Experiments in mouse cellsUrolithin A

International Journal of Molecular SciencesDec 17

Resveratrol and Gut Microbiota Synergy: Preventive and Therapeutic Effects

ReviewResveratrol