GrimAge 2 age acceleration
1 paper5 findings
- Humans1
Effects
1Cardiovascular hospitalisation
no changein humans1
1 study
Cardiovascular hospitalisation
no changein humans1
GrimAge 2 age acceleration has no effect on cardiovascular hospitalisation in humans.
“Kaplan-Meier analysis did not show a difference in the rates of cardiovascular hospitalisation between Grim2AA ≥0 and <0 years (p=0·19).”
HumansGrim2AA ≥0 versus <0 yearsMedian follow-up of 4.68 yearsn = 535
medRxiv10 Jun 2025Preprint
Associations
4ASCVD hospitalisation
upin humans1
1 study
ASCVD hospitalisation
upin humans1
GrimAge 2 age acceleration predicts ASCVD hospitalisation in humans.
“the rates of ASCVD hospitalisation (42 of 101) were significantly higher in older adults with the former (p=0·0027).”
HumansGrim2AA ≥0 versus <0 yearsMedian follow-up of 4.68 yearsn = 535
medRxiv10 Jun 2025Preprint
Atherogenic lipid profile
mixedin humans1
1 study
Atherogenic lipid profile
mixedin humans1
GrimAge 2 age acceleration is associated with atherogenic lipid profile in humans.
“and an atherogenic lipid profile characterised by reduced low-density lipoprotein (LDL) particle size and abnormal triglycerides in lipoproteins.”
Humansserumn = 535
medRxiv10 Jun 2025Preprint
GlycA
upin humans1
1 study
GlycA
upin humans1
GrimAge 2 age acceleration is associated with GlycA in humans.
“Grim2AA was significantly associated with systemic inflammation indicated by GlycA”
Humansn = 535
medRxiv10 Jun 2025Preprint
Frailty
upin humans1
1 study
Frailty
upin humans1
GrimAge 2 age acceleration predicts frailty in humans.
“GrimAge 2-estimated EAA (Grim2AA) performed best in classifying and predicting the frailty phenotype.”
HumansCommunity-living older adults without previous heart failuren = 535
medRxiv10 Jun 2025Preprint