Gja1 expression

1. Bosentan increases Gja1 expression in mice.

   “the decreased expression of connexin 43 (Cx43) in SGCs in aged mice after nerve injury is partially rescued by Bosentan treatment.”

   Animalsafter nerve injurysatellite glial cell

   Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline

   eLife·29 Jul 2025Preprint

More on Bosentan

1. Age is associated with Gja1 expression in mice.

   “CX43 expression in mouse ovaries and granulosa cells markedly decreased in an age-dependent manner”

   Animalsovarian agingovary and granulosa cellfemales

   Intraperitoneal ZP123 improves aged oocyte quality by restoring granulosa cell gap junctions and improving mitochondrial function

   Journal of ovarian research·23 May 2026