bioRxiv
Lifespan-extending downregulation of insulin signalling reduces germline mutation load
Preprint: experiments in wormsMechanisms
Papers on genomic stability
481 papers19 new in 30 days
Friday, January 23
Tuesday, January 20
The Journal of Biological Chemistry
BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication
Experiments in human cellsMechanisms
Monday, January 19
FEBS Open Bio
Nuclear pore links Fob1-dependent rDNA damage relocation to lifespan control
Experiments in yeastMechanisms
Monday, January 12
Aging Cell
Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage
Non-randomized trial in peopleRapamycin
Saturday, January 3
GSA 2025 Abstract
Protective Effects of the FOXO3 Longevity Gene on Aging-Related Diseases in the CHAMP Cohort
Cohort study in peoplePopulations
Thursday, January 1
Molecular Neurobiology
Aryl Hydrocarbon Receptor Signaling in Aging: A Key Modulator of Brain Homeostasis
ReviewMechanisms
Science Advances
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Experiments in miceMechanisms
Wednesday, December 24
Tropical Medicine and Health
Telomere length promotes colorectal cancer through dual parallel pathways involving growth signaling and protein metabolism
Mendelian randomization in 378,749 peopleAmino acid metabolism
Friday, December 12
Saturday, December 6
Mechanisms of Ageing and Development
DHT ameliorates cardiac aging in progeroid mice by XRCC4-mediated genome stabilization
Experiments in miceInterventions
Thursday, December 4
bioRxiv
PARP1 deficiency induces aging-associated cardiac failure via activation of Akt signalling
Preprint: experiments in micePARP1
Friday, November 28
Current Research in Pharmacology and Drug Discovery
Targeting telomere dynamics with plant-derived compounds: Molecular strategies against aging
ReviewInterventions
Thursday, November 13
International Journal of Molecular Sciences
Biomolecular Fingerprints of Sirtuin Activity in Senescent Fibroblasts Identified via Synchrotron-Based FTIR
Experiments in human cellsSirtuin signaling
Wednesday, November 12
Human Genomics
Structural and functional impact of the POLD1 Ser605del variant in MDPL syndrome: insights from protein-protein interactions
Experiments in human cellsMechanisms
Monday, November 10
bioRxiv
The Divergent 3D Genome Landscapes of Aging and Neurodegenerative mouse models
Preprint: experiments in miceMechanisms
Tuesday, November 4
Expert Opinion on Therapeutic Patents
Sirtuin modulators: a review of patents from 2020 to 2024
Systematic reviewInterventions
Wednesday, October 29
Tuesday, October 21
EMBO Reports
Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins
Experiments in zebrafishTelomerase and telomere maintenance
Thursday, October 16
Clinical Interventions in Aging
The Ambiguous Role of HMGB1 Across the Hallmarks of Aging: A Narrative Review
ReviewHMGB1
International Journal of Molecular Sciences
CRISPR and Artificial Intelligence in Neuroregeneration: Closed-Loop Strategies for Precision Medicine, Spinal Cord Repair, and Adaptive Neuro-Oncology
ReviewInterventions
Tuesday, October 14
Annual Review of Pathology
Targeting Genome Stability to Mitigate Human Aging and Disease
ReviewMechanisms
Monday, October 13
bioRxiv
Machine learning-based definition of cellular senescence reveals pro-senescence potential implication in lung adenocarcinoma
Preprint: experiments in human cellsLung adenocarcinoma
Tuesday, September 30
bioRxiv
Imp, a key regulator of transposable elements, cell growth, and differentiation genes during embryogenesis
Preprint: experiments in fliesTransposable element activity
bioRxiv
Rare centenarian SIRT6 variants elevate SIRT6 protein levels and resist cellular senescence
Preprint: experiments in human cellsCellular senescence
Saturday, September 27
Biochemical and Biophysical Research Communications
Mini review: Gene therapy targets for aging-associated diseases
ReviewInterventions
Tuesday, September 9
Aging Cell
STN1 Shields CTC1 From TRIM32-Mediated Ubiquitination to Prevent Cellular Aging
Experiments in human cellsMechanisms
Sunday, August 31
Trends in Cell Biology
The Wnt-NAD⁺ axis in cancer, aging, and tissue regeneration
ReviewWnt/β-catenin signaling