Papers on genomic stability

481 papers19 new in 30 days

Wednesday, August 20

Cell Death and DifferentiationAug 20

PUMA-induced apoptosis drives bone marrow failure and genomic instability in telomerase-deficient mice

Experiments in miceTelomerase and telomere maintenance

Paper

Thursday, August 7

GeroScienceAug 7

The senescence-inhibitory p53 isoform Δ133p53α: enhancing cancer immunotherapy and exploring novel therapeutic approaches for senescence-associated diseases

ReviewCancer

Paper

Sunday, August 3

Cell & BioscienceAug 3

DNA damage response and cell fate decisions across the lifespan: from fetal development to age-related respiratory diseases

ReviewDNA damage response

Paper

Friday, August 1

Pesticide Biochemistry and PhysiologyAug 1

Sublethal effects of dimethoate on energy metabolism and its link to cellular senescence due to impaired mitochondrial respiration and ATP production in SH-SY5Y cells

Experiments in human cellsOxidative phosphorylation

Paper

Tuesday, July 29

International Journal of Molecular SciencesJul 29

Hepatocytes as Model for Investigating Natural Senotherapeutic Compounds and Their Effects on Cell Cycle Dynamics and Genome Stability

ReviewSenotherapeutics

Paper

BiomoleculesJul 29

Methionine Restriction Differentially Modulates Expression of Genes in the Base Excision Repair Pathway in Rat Brain and Liver

Experiments in ratsDietary restriction

Paper

BiomoleculesJul 29

DNA Damage Response Regulation Alleviates Neuroinflammation in a Mouse Model of α-Synucleinopathy

Experiments in miceInterventions

Paper

Wednesday, July 16

bioRxivJul 16

ZNF865 (BLST) Regulates Back Pain via Cell Senescence and DNA Damage Mechanisms

Preprint: experiments in animalsDNA damage response

Paper

Sunday, July 13

NutrientsJul 13

Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial

Randomized trial in 67 peopleInterventions

Paper

Wednesday, July 2

PLOS OneJul 2

Genetic association of intelligence with longevity in Drosophila melanogaster

Experiments in fliesMechanisms

Paper

Tuesday, July 1

Hepatology ResearchJul 1

Investigation of Possible Telomerase Reverse Transcriptase Promoter Mutation in Human Chemically Induced Liver Progenitors

Cross-sectional study in peopleInterventions

Paper

BiogerontologyJul 1

Translational potential of GADD45α: biomarker and therapeutic target in age-associated neurodegeneration and longevity

ReviewMechanisms

Paper

Friday, June 27

BiogerontologyJun 27

Overexpression of the Dicer family genes influences lifespan and stress resistance in a tissue-, sex-, and stressor-specific manner in Drosophila melanogaster

Experiments in fliesMechanisms

Paper

Wednesday, June 25

EpigenomesJun 25

DNA Methylation, Aging, and Cancer

ReviewDNA methylation

Paper

Wednesday, June 18

Science AdvancesJun 18

ZC3H4 safeguards genome integrity by preventing transcription-replication conflicts at noncoding RNA loci

Experiments in cellsMechanisms

Paper

Nucleic Acids ResearchJun 18

Replication stress responses in human lymphocytes change sex-specifically during aging

Study in peopleDNA damage response

Paper

Wednesday, June 11

bioRxivJun 11

TrAEL-seq captures DNA replication dynamics in mammalian cells

Preprint: experiments in cellsAI & data

Paper

Friday, June 6

BioEssaysJun 6

Liquid Guardians: Biomolecular Condensates Shield Heterochromatin Against Cellular Senescence

ReviewCellular senescence

Paper

Wednesday, May 28

AnimalsMay 28

ATR Deficiency Impairs DNA Damage Repair and Accelerates Cellular Senescence in Bovine Mammary Epithelial Cells, Leading to Lactation Dysfunction

Experiments in cellsDNA damage response

Paper

ThoraxMay 28

Epithelial damage and ageing: the perfect storm

ReviewMechanisms

Paper

Friday, May 23

Zoological ResearchMay 23

Features and mechanisms of long-lived Myotis somatic fibroblasts in response to DNA replication stress

Experiments in cellsDNA damage response

Paper

Monday, May 5

BiogerontologyMay 5

ATM and p53 in aging and cancer: a double-edged sword in genomic integrity

ReviewMechanisms

Paper

Wednesday, April 30

Frontiers in BioscienceApr 30

Linker Histones Maintain Genome Stability and Drive the Process of Cellular Ageing

ReviewMechanisms

Paper

Friday, April 25

Journal of Cardiovascular Development and DiseaseApr 25

Telomere Length and Clonal Hematopoiesis of Indeterminate Potential: A Loop Between Two Key Players in Aortic Valve Disease?

ReviewTelomerase and telomere maintenance

Paper

Sunday, April 20

CureusApr 20

Sirtuin Expression in Age-Associated Hepatic Response to Burn Trauma: Translational and Clinical Insights From a Murine Model

Experiments in miceSirtuin signaling

Paper

Friday, April 18

Cell ProliferationApr 18

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

Experiments in cellsInterventions

Paper

Regenerative TherapyApr 18

Targeting p53-p21 signaling to enhance mesenchymal stem cell regenerative potential

ReviewInterventions

Paper

Wednesday, April 16

bioRxivApr 16

SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the aging mouse testis

Preprint: experiments in miceCell cycle regulation

Paper

Sunday, April 13

Human CellApr 13

The influence of cell source on the senescence of human mesenchymal stem/stromal cells

ReviewCellular senescence

Paper

Friday, April 11

Science AdvancesApr 11

Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita

Experiments in miceTelomerase and telomere maintenance

Paper