gBOLD/CSF coupling

1. Time-restricted feeding decreases gBOLD/CSF coupling in humans.

   “while gBOLD-CSF coupling decreased (p = 0.027), approaching healthy control levels.”

   Human trialin metabolic syndromeearly time-restricted eatingbrain1 monthmales

   One-month early time-restricted eating enhances long-term memory by modulating brain fluid dynamics in males with metabolic syndrome: Evidence from perivascular diffusion and global blood-oxygen-level-dependent-cerebrospinal fluid coupling

   Journal of Alzheimer's disease : JAD·8 Jul 2026

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1. gBOLD/CSF coupling is associated with delayed recall in humans (r = -0.550).

   “whereas changes in gBOLD-CSF coupling were negatively correlated (r = -0.550, p < 0.05).”

   Human trialpost-eTRE change in metabolic syndromebrain1 monthmales

   One-month early time-restricted eating enhances long-term memory by modulating brain fluid dynamics in males with metabolic syndrome: Evidence from perivascular diffusion and global blood-oxygen-level-dependent-cerebrospinal fluid coupling

   Journal of Alzheimer's disease : JAD·8 Jul 2026

1. gBOLD/CSF coupling is associated with [18F]MK6240 tau-PET signal in humans.

   “meningeal signal of [ 18 F]MK6240 is significantly associated with glymphatic clearance in females”

   Humanscognitively unimpaired amyloid-β-meningesfemales

   Impact of sex, age and glymphatic clearance on meningeal tau PET signal

   AAIC 2025 abstract·24 Dec 2025

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