Gadd45a

3 papers

Humans1
Animals2

Latest

2 in 12 months

Aging Cell20 Mar

Age-Like Methylation Changes of HSCs in GADD45B Knockout Mice Define Methylation Sites Associated With Loss of Function

Experiments in miceStem cell maintenance

International Immunopharmacology20 Nov

AGK2 and nicotinamide riboside reveal SIRT2's protective role in a diabetic-dietary rat model of NASH via deacetylation of NLRP3, LKB1, and FOXO3a and restoration of AMPK-ACC/PGC-1α-Nrf2 signaling

Experiments in ratsNicotinamide riboside

International Journal of Molecular Sciences13 Nov

Transcriptomic Insights into Late-Life Depression and the Role of Environmental Drinking Water Composition: A Study on 18-Month-Old Mice

Experiments in miceDepression

BMC Musculoskeletal Disorders23 Mar

Bioinformatics and machine learning approaches to explore key biomarkers in muscle aging linked to adipogenesis

Experiments in miceBiomarkers

Placenta6 Feb

Lactate promotes premature aging of preeclampsia placentas through histone lactylation-regulated GADD45A

Study in peopleEpigenetic regulation of gene expression

bioRxiv9 Dec

Insights into the causes and consequences of DNA repeat expansions from 700,000 biobank participants

Preprint: study in peopleMechanisms

JCI Insight10 Oct

GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle

Experiments in animalsMechanisms

Journal of Cachexia, Sarcopenia and Muscle29 Nov

Loss of FoxOs in muscle increases strength and mitochondrial function during aging

Experiments in miceOxidative phosphorylation

Advances in Experimental Medicine and Biology4 May

Gadd45 in Senescence

ReviewMechanisms

EMBO Reports20 Aug

Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan

Experiments in miceTelomerase and telomere maintenance