FSH and LH

1. Dehydroepiandrosterone decreases FSH and LH in aging men with partial androgen deficiency, uncontrolled before-and-after design.

   “while FSH, LH and SHBG levels showed a significant decrease”

   Human trialin aging men with partial androgen deficiency, uncontrolled before-and-after design25 mg/day1 yearmales

   Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency

   The aging male : the official journal of the International Society for the Study of the Aging Male·Jun 1, 2004

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1. Gynodian-depot decreases FSH and LH in humans (Suppression in about half of determinations).

   “Post-menopausally increased FSH and LH fractions were markedly suppressed in about half of the determinations after Gynodian-Depot administration”

   Human trial1 ampoule monthlyfemales

   Catabolic effects and the influence on hormonal variables under treatment with Gynodian-Depot or dehydroepiandrosterone (DHEA) oenanthate

   Maturitas·Dec 1, 1981

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1. FSH and LH predicts weight loss in humans (particularly during perimenopause) (p<0.05).

   “Circulating FSH and LH delineated menopausal status and predicted WL magnitude, particularly during perimenopause (p<0.05; Fig. A).”

   Human trialparticularly during perimenopause

   Menopausal Hormonal Status and Estradiol Use Modulate Semaglutide-Associated Weight Loss in Women: Analyses from STEP1 and SELECT

   ADA Scientific Sessions 2026 abstract·Jun 5, 2026