Mechanisms of Ageing and Development·Sep 9MicroRNA-322 promotes granulosa cell senescence and premature ovarian failure by suppressing Klotho expression and cell cycle progressionExperiments in miceCell cycle regulationPaper
Functional & Integrative Genomics·Sep 7Age-associated chromatin repression of Hippo-Yap signaling drives oogonial stem cell decline in chickenExperiments in cellsHippo–YAP signalingPaper
Biochimica et Biophysica Acta Molecular Basis of Disease·Aug 16Aspartame triggers premature ovarian failure via SIRT1-dependent suppression of the PI3K/AKT/mTOR pathway and induction of oxidative stress and apoptosisExperiments in ratsPI3K–AKT signalingPaper
Biology of Reproduction·Aug 6Ovarian Antral Follicle Toxicity Induced by Phthalate ExposuresReviewReproductive systemPaper
Reproductive Biology and Endocrinology·Jul 21Theca cells: active orchestrators of ovarian agingReviewReproductive systemPaper
Theriogenology·Jun 29Sirtuin 3 alleviates ovarian granulosa cell senescence through regulating mitochondrial quality controlExperiments in cellsSirtuin signalingPaper
Environment & Health·Jun 25Prenatal Exposure to PFOA Induces Ovarian Function Impairment via the Disruption of the PPARγ/ANGPTL4 PathwayExperiments in animalsMechanismsPaper
Journal of Animal Science and Biotechnology·Jun 7Mechanistic understanding of female reproductive aging based on the chicken modelReviewReproductive systemPaper
European Journal of Histochemistry·Apr 21Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cellsExperiments in miceSenolyticsPaper
Journal of Genetics and Genomics·Apr 4Probiotic potential of Parabacteroides johnsonii in mitigating age-related ovarian functional declineExperiments in miceReproductive systemPaper
iScience·Mar 18Metabolic, epigenetic, and immune crosstalk in ovarian agingReviewReproductive systemPaper
Journal of Ovarian Research·Mar 14Quercetin ameliorates cyclophosphamide-induced premature ovarian insufficiency by modulating SIRT1/HIF-1α pathwayExperiments in miceQuercetinPaper
Cellular and Molecular Life Sciences·Feb 28Inflammatory bowel disease leads to long-term ovarian dysfunction via immune-mediated follicular agingExperiments in miceImmune responsePaper
Poultry Science·Feb 16Dietary genistein supplementation enhances reproductive and bone health in late-laying hensExperiments in 180 chickensReproductive systemPaper
BMC Biology·Feb 14Axolotls retain fertility throughout lifespanExperiments in axolotlsReproductive systemPaper
Current Environmental Health Reports·Feb 13Mechanisms of Phthalate-Induced Accelerated Ovarian Aging in Experimental ModelsReviewReproductive systemPaper
Poultry Science·Feb 8miRNA profiling reveals that gga-let-7i/COL1A2 axis induces cell cycle arrest and triggers cellular senescence to accelerate ovarian aging in laying hens by suppressing the PI3K/AKT/MDM2 pathwayExperiments in chickensPI3K–AKT signalingPaper
BMC Genomics·Feb 4Integrated analysis of differential m6A methylation and transcriptome profiles in ovaries of young and aged Qira black sheepExperiments in sheepReproductive systemPaper
International Journal of Molecular Sciences·Jan 28Oxidative Stress and SIRT1-Nrf2 Anti-Ferroptotic Pathways in Granulosa Cells: A Molecular Key to Follicular Atresia and Ovarian AgingReviewFerroptosisPaper
Cells·Nov 13Preventive Effect of Fisetin on Follicular Granulosa Cells Senescence via Attenuating Oxidative Stress and Upregulating the Wnt/β-Catenin Signaling PathwayExperiments in cellsFisetinPaper
Free Radical Biology & Medicine·Jul 31Investigation of NAD+ metabolism alterations during follicular atresia in porcine ovaries and their regulatory mechanisms in granulosa cell apoptosisExperiments in pig cellsNAD+ metabolismPaper
Journal of Ovarian Research·Jun 19Ovarian remodeling and aging-related chronic inflammation and fibrosis in the mammalian ovaryCohort study in peopleInflammationPaper
Stem Cell Research & Therapy·May 30Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescenceExperiments in miceDiminished ovarian reservePaper
EBioMedicine·Apr 18CKAP5 deficiency induces premature ovarian insufficiencyExperiments in miceReproductive systemPaper
FASEB Journal·Mar 18Ovarian aging-associated downregulation of GPX4 expression regulates ovarian follicular development by affecting granulosa cell functions and oocyte qualityStudy in peopleGPX4Paper
Antioxidants·Jan 8Flavonoid Fisetin Alleviates Ovarian Aging of Laying Chickens by Enhancing Antioxidant Capacity and Glucose Metabolic HomeostasisExperiments in chickensFisetinPaper
Antioxidants·Dec 30β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK PathwayExperiments in cellsNicotinamide mononucleotidePaper
Antioxidants·Aug 31Pterostilbene, a Resveratrol Derivative, Improves Ovary Function by Upregulating Antioxidant Defenses in the Aging Chickens via Increased SIRT1/Nrf2 ExpressionExperiments in 36 chickensReproductive systemPaper
iScience·Jul 26Type III adenylyl cyclase is essential for follicular development in female mice and their reproductive lifespanExperiments in miceReproductive systemPaper
Poultry Science·Apr 18Melatonin alleviates endoplasmic reticulum stress to improve ovarian function by regulating the mTOR pathway in aged laying hensExperiments in chickensMelatoninPaper