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Biochimica et Biophysica Acta Molecular Basis of Disease

Aspartame triggers premature ovarian failure via SIRT1-dependent suppression of the PI3K/AKT/mTOR pathway and induction of oxidative stress and apoptosis

By Xinyue Liu, Chunqi Feng, Ting Zhu, Show 4 more authorsYuping Suo
Experiments in ratsMechanisms

8 weeks, dose-response

Paper

The paper

Xinyue Liu, Chunqi Feng, Ting Zhu, Show 4 more authorsYuping Suo

Shanxi Medical University

Biochimica et Biophysica Acta Molecular Basis of Disease, 16 Aug 2026

doi.org/10.1016/j.bbadis.2026.168425PubMed 42604715

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