DNA methylation level and entropy over PRC2 targets

1. Partial reprogramming increases DNA methylation level and entropy over PRC2 targets in mice.

   “We found a striking convergence of age- and rejuvenation-related epigenetic alterations on targets of the Polycomb repressive complex 2 (PRC2), with increased DNA methylation level and entropy over these regions.”

   Animalspartial reprogramming in physiologically aging miceskin

   Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets

   Molecular systems biology·10 Feb 2026

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