1 paper3 findings
Atrial fibrillation risk prediction
no changein humans1
Deviation-from-normative-twin scores have no effect on atrial fibrillation risk prediction in humans.
“the independent MeshHeart cVAE representation (which showed no signal for atrial fibrillation)”
HumansPreserved ejection fraction subgroupMeshHeart cVAEheart
Heart shape scores improved prediction of a heart rhythm disorder
medRxiv13 Oct 2026Preprint
Incident stroke
upin humans1
Deviation-from-normative-twin scores predict incident stroke in humans (Incremental C-index +0.024).
“a separate, smaller effect for incident stroke in the same preserved-EF subgroup in the independent MeshHeart cVAE representation”
HumansPreserved ejection fraction (at least 50%); incremental prediction beyond conventional cardiac biomarkersMeshHeart cVAEheart
Heart shape scores improved prediction of a heart rhythm disorder
medRxiv13 Oct 2026Preprint
Incident atrial fibrillation
upin humans1
Deviation-from-normative-twin scores predict incident atrial fibrillation in humans (Incremental C-index +0.068; 5-fold cross-validated +0.063).
“The strongest effect was seen for incident atrial fibrillation among individuals with preserved ejection fraction (at least 50%): incremental C-index delta C = +0.068”
HumansPreserved ejection fraction (at least 50%); incremental prediction beyond conventional cardiac biomarkersHeartSSMheart
Heart shape scores improved prediction of a heart rhythm disorder
medRxiv13 Oct 2026Preprint
In people with preserved heart pumping, adding scores to standard measurements improved the concordance index, a measure of predictive accuracy, by 0.068.In people with preserved heart pumping, adding scores to standard measurements improved the concordance index, a measure of predictive accuracy, by 0.068.