Circulating proteome

1. Circulating proteome mediates all-cause dementia in humans (57 mediating proteins (FDR-p< 0.05)).

   “We found 57 mediating proteins for all-cause dementia (FDR-p< 0.05), mostly from inflammation and cardiometabolic function panels”

   Humansinitially free of dementia13.2 yearsn = 33,852

   MEDIATING PROTEINS UNDERLYING THE RELATIONSHIP BETWEEN MITOCHONDRIAL DNA COPY NUMBER AND DEMENTIA FROM TWO COHORTS

   GSA 2024 abstract·Dec 31, 2024

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1. Circulating proteome predicts heart failure propensity in humans.

   “we link the circulating proteome to human heart failure (HF) propensity (via echocardiographic phenotyping and clinical outcomes) across the lifespan”

   Humansacross the lifespan

   Clinical-transcriptional prioritization of the circulating proteome in human heart failure

   Cell reports. Medicine·Sep 2, 2024

1. Body mass index is associated with circulating proteome in silico (6 proteins).

   “MR estimates provided further corroborative evidence for a role of BMI in regulating the levels of six proteins”

   In silico

   Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome

   Scientific reports·Nov 29, 2023

1. Bariatric surgery is associated with circulating proteome in humans (23 proteins).

   “Twenty-three proteins were altered in a consistent direction after both bariatric surgery and caloric restriction”

   Human trial

   Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome

   Scientific reports·Nov 29, 2023

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