Circulating NAD+
2 papers2 findings
- Human trial1
Interventions
2Nicotinamide adenine dinucleotide
no changein humans1
1 study
Nicotinamide adenine dinucleotide
no changein humans1
Nicotinamide adenine dinucleotide has no effect on circulating NAD+ in humans (unchanged (p=0.60)).
“while cirNAD was unchanged (p=0.60), demonstrating compartment-selective augmentation.”
Human trialhealthy adultsplasma5 daysn = 50
bioRxiv (Cold Spring Harbor Laboratory)27 Mar 2026Preprint
NAD+ precursors
upin humans1
1 study
NAD+ precursors
upin humans1
NAD+ precursors increase circulating NAD+ in humans.
“oral NAD+-precursor supplementation consistently elevates circulating NAD+ in middle-aged and older adults”
Review
Hypothesis-Generating Brief: NAD+ Effects — full paper
Preprint1 Jan 2026Preprint
Latest
6 in 12 monthsGeroScience
Association between whole-blood NAD+ concentration and frailty in community-dwelling older adults: the Itabashi Longitudinal Study on Aging
Cross-sectional study of 529 peopleNAD+
Kidney International Reports
Nicotinamide Adenine Dinucleotide Augmentation in Diabetic Kidney Disease: Randomized Trial Study Protocol
Study protocolDiabetic kidney disease
bioRxiv
Oral LNAD+ Rapidly Elevates Intracellular NAD and Metabolic Flux Without Elevating Circulating NAD: Evidence from a Randomized Controlled Trial
Preprint: randomised trial in 50 peopleInterventions
Nature Medicine
De novo NAD⁺ biosynthetic impairment in acute kidney injury in humans
Randomised trial in peopleAcute kidney injury