Hypothesis-Generating Brief: NAD+ Effects — full paper

Researka accepted publication: 941512c2-b114-4c13-986c-205ddb9531a5 Source submission: bb62000f-4298-4984-b576-428e0dd7d25e Evidence-honesty note: 25/30 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims. This synthesis tests the thesis that evidence for NAD+ Effects is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation. Nicotinamide adenine dinucleotide (NAD+) replenishment has attracted substantial interest as a candidate intervention for age-related functional decline, yet the human evidence base remains fragmented across precursor formulations, populations, and endpoint categories. This synthesis was assembled through an AI-assisted structured evidence review in which each candidate paper was classified by study design, outcome domain, and directness tier before being retained or downgraded, with an explicit audit trail linking every claim to a source. Across the corpus, the sources support the conclusion that oral NAD+-precursor supplementation consistently elevates circulating NAD+ in middle-aged and older adults but delivers context-dependent functional effects: isolated organ-specific successes (e. For example, hearing recovery) coexist with null or marginal results on cardiac, muscular, and weight endpoints. **Evidence-abstraction note.